Table 2.

Correlation of 44 metabolites concentrations after creatinine-, osmolality- and regression-based normalization. Pearson correlation coefficients of three pairwise comparisons are shown. Non-significant correlations are indicated in bold (Bonferroni cut off; p-values < 1.14 × 10⁻³). In summary, absolute correlation coefficients > 0.15 reflect a statistical significance.

Metabolite	Creatinine Normalization vs. Osmolality Normalization	Osmolality Normalization vs. RBN	RBN vs. Creatinine Normalization
C0	0.76	0.84	0.97
C2	0.84	0.85	0.98
C3	0.68	0.76	0.96
C4:1	0.93	0.93	0.99
C5	0.73	0.89	0.93
C5-M-DC	0.75	0.83	0.96
C5:1	0.62	0.79	0.93
C5:1-DC	0.68	0.76	0.95
C6:1	0.13	0.55	0.71
C7-DC	0.21	0.56	0.79
C8	−0.01	0.49	0.61
C8:1	0.70	0.72	0.96
C9	0.65	0.77	0.93
C10	−0.08	0.49	0.57
C10:1	0.18	0.49	0.79
C10:2	0.74	0.82	0.96
C12	0.09	0.63	0.64
C14	0.16	0.66	0.56
C14:1	0.23	0.70	0.70
C14:1-OH	0.16	0.70	0.61
C14:2	0.12	0.64	0.62
C14:2-OH	0.05	0.61	0.57
C16	0.47	0.78	0.77
C16-OH	0.68	0.90	0.86
C16:2	0.19	0.75	0.48
C18:2	0.32	0.76	0.49
Arg	0.33	0.44	0.80
Gln	0.44	0.50	0.86
Gly	0.64	0.60	0.92
His	0.58	0.51	0.90
Met	−0.09	0.35	0.61
Phe	0.42	0.52	0.87
Pro	0.22	0.42	0.71
Ser	0.44	0.55	0.85
Thr	0.50	0.53	0.89
Trp	0.21	0.41	0.81
Tyr	0.48	0.49	0.88
Val	0.28	0.36	0.75
Leu/Isoleu	0.45	0.36	0.76
Creatinine	-	0.20	-
PC ae C38:3	0.44	0.83	0.61
PC ae C38:6	0.11	0.55	0.66
SM C24:0	0.44	0.80	0.72
H1	0.50	0.59	0.88