Table 1.

Comparison of the potent synthetic modulators in vitro.

Reference	Compound	Target	Cytotoxicity (µM)
Ting-Chao Chou [49]	N3	P-gp	CCRF-CEM: 13	CCRF-CEM/VBL1000: 100
Bin [50]	Compound 35	P-gp	L292: >100	MDA435/LCC6: >100	MDA435/LCC6MDR: >100
Yang [45]	Compound 23	P-gp	L292: >100	MDA435/LCC6: >100	MDA435/LCC6MDR: >100
Wang [51]	Compound 12	P-gp	L292: >100	MDA435/LCC6: >100	MDA435/LCC6MDR: >100
Chen [53]	5 Bromo-tetrandrine	P-gp	KB: 5.14	KBv200: 6.17
Sun [54]	W6	P-gp	KB: ~2	KBv200: ~4	MCF-7: ~4.5	MCF-7/DOX: ~5
Zhu [55]	Compound 26	P-gp	HepG2/ADR: >150	MCF-7/ADR: >150
Kraege [29]	GO-Y078	BCRP	K562/BCRP: 0.31
Wong [56]	Compound 51	MRP1, P-gp and BCRP	L292: >100	LCC6: >100	LCC6MDR: >100
Wong [56]	4e	MRP1	L292: >100	LCC6: >100	LCC6MDR: >100