Table 3.
Pharmacokinetics parameters after bolus i.v. injection via tail vein of Kunming mice (n = 3) against various drug treatments e.g., free drug solutions (DOX and OA) and liposomes [DOX loaded (DXL), OA loaded (OAL), and (combined (ODL)].
| PK Parameters | DOX | DXL | OA | OAL | ODL | |
|---|---|---|---|---|---|---|
| DOX | OA | |||||
| Cmax (µg/mL) | 0.91 ± 0.12 | 10.78 ± 1.5 | 90.83 ± 17.11 | 172.81 ± 14.72 | 5.17 ± 0.5 | 130.74 ± 10.07 |
| AUCtot (µg/mL/h) | 1.18 ± 0.15 | 176.54 ± 9.93 | 98.83 ± 24.12 | 2135.24 ± 107.24 | 124.05 ± 2.68 | 1846.38 ± 79.35 |
| T1/2 (h) | 0.6 ± 0.33 | 12 ± 2.25 | 0.6 ± 0.14 | 10.84 ± 1.86 | 8.49 ± 0.65 | 8.86 ± 0.55 |
| Vd (mL) | 84.69 ± 44.08 | 16.68 ± 3.53 | 7.68 ± 0.59 | 6.93 ± 0.82 | 16.87 ± 1.12 | 6.14 ± 0.16 |
| CL (mL/h) | 99.02 ± 15.92 | 0.97 ± 0.17 | 9.34 ± 2.22 | 0.45 ± 0.03 | 1.38 ± 0.03 | 0.48 ± 0.03 |
| MRT (h) | 1.74 ± 0.16 | 19.11 ± 2.61 | 0.88 ± 0.16 | 16.32 ± 2.04 | 18.2 ± 0.92 | 13.04 ± 0.82 |
Cmax: peak plasma concentration: AUCtot: Total area under the curve; T1/2: half-life; Vd: volume of distribution: CL: clearance: MRT: mean residence time.