Table 1.
Test Material | Effective Permeability Across an Artificial Membrane (Pe, ×10−6, cm/s) | Apparent Permeability Across a Caco-2 Cell Monolayer (Papp, ×10−6, cm/s) |
---|---|---|
PMX in water | 6.03 ± 1.41 | 1.57 ± 0.749 |
PMX/DCK | 15.3 ± 3.65 *** | 11.9 ± 1.47 *** |
PMX/DCK-NE | 33.1 ± 0.739 ***,### | 15.8 ± 3.53 ***,# |
QCN in water | 0.000± 0.000 | 0.550 ± 0.032 |
QCN in 0.3% NaCMC | 1.20 ± 0.527 ** | 2.21 ± 0.533 |
QCN-NE | 16.6 ± 0.621 ***,$$$ | 8.46 ± 2.21 ***,$$$ |
Values are expressed as mean ± standard deviation (n = 6). ** p < 0.01, *** p < 0.001 compared with PMX or QCN in water; # p < 0.05, ### p < 0.001 compared with PMX/DCK; $$$ p < 0.001 compared with QCN in 0.3% NaCMC.