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. 2018 Sep 5;10(3):148. doi: 10.3390/pharmaceutics10030148

Table 3.

AUC values for mass flux and lag time obtained from the KTP permeation profiles of the gel and the suspension using three cells and two membranes (cellulose and Strat-M membranes) in two media at 37 °C.

Matrix of KTP Permeation Parameters Conditions
Media pH: 5.6 Media pH: 7.4
Cell A Cell B Cell C Cell A Cell B Cell C
Gel Cellulose membrane
Flux (mol/cm2 h) × 104 2.68 ± 0.08 2.53 ± 00.9 2.71 ± 0.01 2.54 ± 0.03 2.75 ± 0.08 2.77 ± 0.01
Lag-time (h) 0.04 0.013 0.007 0.12 0.107 0.119
Strat-M membrane
Flux (mol/cm2 h) × 104 2.07 ± 0.08 2.12 ± 0.08 2.10 ± 0.08 1.96 ± 0.03 2.00 ± 0.09 1.94 ± 0.01
Lag-time (h) 0.012 0.056 0.055 0.433 0.457 0.179
Simple suspension Cellulose membrane
Flux (mol/cm2 h) × 104 2.82 ± 0.04 2.83 ± 0.10 2.81 ± 0.07 2.03 ± 0.12 2.07 ± 0.05 2.18 ± 0.07
Lag-time (h) 0.108 0.101 0.109 0.126 0.130 0.142
Strat-M membrane
Flux (mol/cm2 h) × 104 0.25 ± 0.03 0.27 ± 0.01 0.27 ± 0.01 0.18 ± 0.01 0.10 ± 0.02 0.10 ± 0.03
Lag-time (h) 0.298 0.221 0.225 0.324 0.329 0.382