Table 2.
Patients with septic shock (Shock-2 and Shock-3 definition) treated with albumin or crystalloids
| Shock 2 N = 1098 |
Shock 3 N = 721 |
|||||
|---|---|---|---|---|---|---|
| Albumin N = 549 |
Crystalloids N = 549 |
p value | Albumin N = 346 |
Crystalloids N = 375 |
p value | |
| MAP (mmHg) | 70.9 ± 14.4 | 70.8 ± 14.1 | 0.958a | 70.4 ± 14.8 | 69.0 ± 14.0 | 0.190a |
| CVP (mmHg) | 10.8 ± 5.0 | 10.8 ± 4.9 | 0.877a | 11.0 ± 5.1 | 10.8 ± 4.9 | 0.583a |
| HR (bpm) | 106.5 ± 22.1 | 106.8 ± 20.4 | 0.819a | 109.8 ± 21.5 | 109.2 ± 19.8 | 0.672a |
| SvO2 (%) | 71.4 ± 11.14 | 73.3 ± 10.0 | 0.005a | 70.7 ± 11.9 | 73.0 ± 10.2 | 0.007a |
| PaCO2 (mmHg) | 39.2 ± 12.4 | 39.2 ± 9.7 | 0.960a | 38.1 ± 11.4 | 38.67 ± 9.8 | 0.455 |
| PvCO2 (mmHg) | 46.7 ± 12.6 | 46.3 ± 10.3 | 0.524a | 45.9 ± 11.8 | 45.69 ± 10.7 | 0.833a |
| Noradrenaline (μg/kg/min) | 1.9 ± 0.8 | 1.3 ± 0.6 | 0.042a | 1.9 ± 0.9 | 1.3 ± 0.6 | 0.126a |
| Patients on noradrenaline | 463 (84.3%) | 458 (83.4%) | 0.682c | 296 (85.5%) | 321 (85.6%) | 0.985c |
| Lactate (mmol/L) | 3.7 ± 3.2 | 4.1 ± 3.4 | 0.040b | 5.11 ± 3.3 | 5.31 ± 3.4 | 0.487b |
| pH | 7.40 ± 0.1 | 7.4 ± 0.1 | 0.883a | 7.35 ± 0.1 | 7.34 ± 0.1 | 0.597a |
| BE (mmol/L) | −3.9 ± 6.1 | −3.7 ± 6.2 | 0.800b | −4.8 ± 6.2 | −4.6 ± 6.2 | 0.937b |
| Albumin (g/L) | 23.5 ± 6.3 | 24.1 ± 6.1 | 0.138b | 23.4 ± 6.4 | 23.9 ± 6.2 | 0.617b |
| Creatinine (mg/dL) | 2.2 ± 1.7 | 2.1 ± 1.5 | 0.153a | 2.3 ± 1.6 | 2.2 ± 1.5 | 0.175a |
| Diuresis (ml/h) | 70.6 ± 71.1 | 72.7 ± 76.5 | 0.610b | 68.8 ± 73.3 | 69.2 ± 75.7 | 0.847b |
| Fluid balance (6 h) (L) | 1.2 ± 1.4 | 1.2 ± 1.7 | 0.549b | 1.4 ± 1.5 | 1.5 ± 1.8 | 0.918b |
| Fluid input (day 1) (L) | 4.8 ± 2.3 | 4.8 ± 2.3 | 0.917b | 5.1 ± 2.4 | 5.1 ± 2.5 | 0.710b |
| SOFA | 9.3 ± 2.6 | 9.4 ± 2.8 | 0.782b | 9.9 ± 2.7 | 9.9 ± 2.8 | 0.906b |
| SAPS II | 52.1 ± 17.0 | 52.7 ± 17.1 | 0.592a | 55.6 ± 17.0 | 55.8 ± 17.1 | 0.911a |
| Mortality (90 day) | 237 (43.6%) | 270 (49.8%) | 0.039c | 167 (48.7%) | 203 (54.9%) | 0.099c |
| WBC | 13.4 ± 10.3 | 13.2 ± 10.8 | 0.762a | 12.9 ± 11.0 | 12.6 ± 11.5 | 0.644a |
| PLT | 176 ± 118 | 181 ± 131 | 0.873b | 156 ± 109.9 | 164 ± 126.1 | 0.592b |
Physiological and outcome variables (mean ± standard deviation or number (percentage)) measured at baseline in patients classified according to the criteria for septic shock adopted in the ALBIOS trial compared to the Shock-3 definition
MAP mean arterial pressure, CVP central venous pressure, HR heart rate, SvO2 central venous saturation, PaCO2 arterial CO2 partial pressure, PvCO2 venous CO2, partial pressure, BE base excess, SOFA Sepsis-related Organ Failure Assessment, SAPS-II Simplified Acute Physiology Score II, WBC white cell count, PLT platelet count
aAnalysis of variance for continuous normally distributed variables
bMann–Whitney test for continuous non-normally distributed variables
cChi-square test for discrete variables