Table 3.
Overall and Progression Free Survival After 3, 5 and 10 Years in Relation to Smoking Habit, SLPI Expression, HPV Status T- and N Category
| n | 3 yrs. [%] | 5 yrs. [%] | 10 yrs. [%] | Mean [yrs] | std [yrs] | Median [yrs] | Min [yrs] | Max [yrs] | P Value | |
|---|---|---|---|---|---|---|---|---|---|---|
| Overall survival | ||||||||||
| Smoking habit | ||||||||||
| Non-smoker | 66 | 78.5 | 70.5 | 51.7 | 7.13 | 4.85 | 7.17 | 0.34 | 30.85 | 0.217 |
| Smoker | 33 | 78.8 | 75.8 | 62.7 | 7.54 | 5.23 | 7.84 | 0.08 | 25.93 | |
| SLPI | ||||||||||
| Negative/weak | 56 | 78.6 | 71.2 | 52.0 | 7.32 | 4.75 | 7.30 | 0.58 | 30.85 | 0.502 |
| Moderate/strong | 43 | 78.7 | 73.7 | 60.2 | 7.19 | 5.27 | 7.84 | 0.08 | 25.93 | |
| HPV | ||||||||||
| Negative | 89 | 78.4 | 71.4 | 55.8 | 7.31 | 5.13 | 7.50 | 0.08 | 30.85 | 0.972 |
| Positive | 10 | 80.0 | 80.0 | 6.90 | 3.16 | 7.75 | 0.58 | 9.93 | ||
| T category | ||||||||||
| Cis | 8 | 87.5 | 87.5 | 87.5 | 11.75 | 8.74 | 9.93 | 2.83 | 30.85 | 0.027 |
| T1a/1b | 40 | 85.0 | 77.3 | 58.2 | 7.77 | 4.53 | 7.72 | 1.08 | 25.93 | |
| T2/T3 | 51 | 70.1 | 66.0 | 47.4 | 6.16 | 4.09 | 7.09 | 0.08 | 14.09 | |
| N category | ||||||||||
| cN0/pN0 | 72 | 81.7 | 74.4 | 60.6 | 7.75 | 5.20 | 7.84 | 0.34 | 30.85 | 0.115 |
| pN1 | 12 | 75.0 | 75.0 | 43.8 | 6.50 | 3.97 | 6.17 | 0.50 | 13.09 | |
| pN2/N3 | 10 | 50.0 | 50.0 | 37.5 | 5.31 | 4.69 | 3.88 | 0.08 | 12.59 | |
| HPV /N category | ||||||||||
| HPV+ cN0/pN0 | 6 | 100 | 100 | 8.66 | 1.22 | 8.76 | 6.84 | 9.93 | 0.006 | |
| HPV+ pN1 | 1 | 100 | 100 | 6.68 | 6.68 | 6.68 | 6.68 | |||
| HPV+ pN2/3 | 2 | 1.33 | 1.08 | 1.33 | 0.58 | 2.08 | ||||
| HPV- cN0/pN0 | 66 | 80.0 | 72.0 | 59.0 | 7.66 | 5.41 | 7.71 | 0.34 | 30.85 | |
| HPV- pN1 | 11 | 72.7 | 72.7 | 40.9 | 6.48 | 4.16 | 5.84 | 0.50 | 13.09 | |
| HPV- pN2/3 | 8 | 62.5 | 62.5 | 46.9 | 6.31 | 4.73 | 7.51 | 0.08 | 12.59 | |
| Progression free survival | ||||||||||
| Smoking habit | ||||||||||
| Non-smoker | 66 | 67.7 | 65.9 | 53.8 | 5.55 | 3.84 | 5.55 | 0.34 | 12.59 | 0.031 |
| Smoker | 33 | 87.1 | 87.1 | 79.2 | 6.56 | 3.88 | 7.59 | 0.08 | 12.92 | |
| SLPI | ||||||||||
| Negative/weak | 56 | 78.0 | 78.0 | 68.9 | 6.04 | 3.60 | 6.76 | 0.50 | 12.59 | 0.044 |
| Moderate/strong | 43 | 69.0 | 66.5 | 52.5 | 5.68 | 4.21 | 6.00 | 0.08 | 12.92 | |
| HPV | ||||||||||
| Negative | 89 | 72.4 | 71.1 | 59.3 | 5.79 | 3.91 | 5.84 | 0.08 | 12.92 | 0.023 |
| Positive | 10 | 88.9 | 88.9 | 6.76 | 3.42 | 7.75 | 0.58 | 9.93 | ||
| T category | ||||||||||
| Cis | 8 | 100 | 100 | 66.7 | 7.56 | 3.15 | 7.97 | 2.83 | 11.84 | 0.233 |
| T1a/1b | 40 | 79.6 | 76.8 | 69.6 | 6.54 | 3.69 | 7.05 | 0.58 | 12.59 | |
| T2/T3 | 51 | 65.3 | 65.3 | 56.1 | 5.11 | 3.98 | 5.42 | 0.08 | 12.92 | |
| N category | ||||||||||
| cN0/pN0 | 72 | 79.1 | 79.1 | 69.2 | 6.43 | 3.65 | 7.13 | 0.34 | 12.84 | 0.042 |
| pN1 | 12 | 50.0 | 41.7 | 41.7 | 4.34 | 4.03 | 3.55 | 0.42 | 12.92 | |
| pN2/N3 | 10 | 62.5 | 62.5 | 41.7 | 4.33 | 4.72 | 1.80 | 0.08 | 12.59 | |
| HPV /N category | ||||||||||
| HPV+ cN0/pN0 | 6 | 100 | 100 | 8.66 | 1.21 | 8.76 | 6.86 | 9.93 | 0.018 | |
| HPV+ pN1 | 1 | 100 | 100 | 6.68 | 6.68 | 6.68 | 6.68 | |||
| HPV+ pN2/3 | 2 | 0.62 | 0.56 | 0.62 | 0.58 | 0.66 | ||||
| HPV- cN0/pN0 | 66 | 77.2 | 77.2 | 66.0 | 6.23 | 3.73 | 7.01 | 0.34 | 12.84 | |
| HPV- pN1 | 11 | 45.5 | 36.4 | 36.4 | 4.12 | 4.16 | 2.75 | 0.42 | 12.92 | |
| HPV- pN2/3 | 8 | 71.4 | 71.4 | 47.6 | 5.25 | 4.74 | 3.76 | 0.08 | 12.58 | |