Table 1.

Baseline characteristics by diagnosis and amyloid status

Characteristic	Cognitively normal		Mild cognitive impairment		Alzheimer-type dementia
	Amyloid negative	Amyloid positive	Amyloid negative	Amyloid positive	Amyloid negative	Amyloid positive
N, % within diagnosis	245 (73)	92 (27)	140 (37)	235 (63)	3 (3)	95 (97)
Age (years)	66.1 ± 7.2	67.5 ± 7.2	67.3 ± 8.0	70.2 ± 7.0***	63.1 ± 8.0	67.1 ± 7.7
Male gender	120 (49)	47 (51)	73 (52)	105 (45)	3 (100)	48 (51)
Education (years)	13.2 ± 3.5	12.8 ± 3.8	10.8 ± 4.0	11.1 ± 3.7	10.3 ± 5.1	11.1 ± 3.3
MMSE	28.9 ± 1.2	28.8 ± 1.2	27.1 ± 2.2	26.0 ± 2.6***	27.7 ± 1.2	22.4 ± 4.0**
Memory immediate	0.10 ± 1.00	0.08 ± 1.10	− 0.64 ± 1.32	−1.22 ± 1.44***	−0.45 ± 0.91	−2.25 ± 1.06
Memory delayed	0.25 ± 1.01	0.30 ± 1.09	−0.90 ± 1.29	− 1.37 ± 1.41**	−0.96 ± 1.33	− 2.28 ± 1.04
Language	−0.21 ± 1.01	0.01 ± 1.04	−0.65 ± 1.30	−0.88 ± 1.27	−0.76 ± 0.38	−1.95 ± 1.02*
Attention	0.32 ± 1.03	0.26 ± 0.89	−0.74 ± 1.79	−0.81 ± 1.63	0.54 ± 0.52	− 2.03 ± 1.94*
Executive functioning	0.35 ± 1.09	0.12 ± 1.15	− 0.76 ± 1.89	−1.11 ± 1.98*	0.46 ± 0.32	−2.49 ± 2.46*
Visuo-construction	− 0.23 ± 1.36	− 0.19 ± 1.20	0.18 ± 1.46	−0.30 ± 1.66*	−0.59 ± 2.09	−1.30 ± 2.00
APOE ε4 genotype	89 (36)	53 (58)***	27 (19)	160 (66)***	2 (67)	66 (69)
Available markers
Visual	245 (100)	92 (100)	140 (100)	235 (100)	3 (100)	95 (100)
Subcortical volumes	240 (98)	90 (98)	130 (93)	230 (98)*	2 (67)	89 (94)
Cortical thickness	232 (95)	88 (96)	119 (85)	200 (85)	2 (67)	88 (93)

Data presented as mean ± standard deviation or count (%). Demographic characteristics based on maximum available data (visual rating)

APOE apolipoprotein E, MMSE Mini-Mental State Examination

*p < 0.05, **p < 0.01, ***p < 0.001, difference between amyloid positive and negative within diagnostic group