Table 3.
Quantitative MRI measures according to diagnosis and amyloid status
| MRI measure | Cognitively normal | Mild cognitive impairment | Alzheimer-type dementia | F value | |||||
|---|---|---|---|---|---|---|---|---|---|
| Amyloid negative | Amyloid positive | Amyloid negative | Amyloid positive | Amyloid negative | Amyloid positive | Diagnosis | Amyloid | Diagnosis × amyloid | |
| Hippocampus left | 3837 (39) | 3752 (58) | 3638 (46) | 3353 (47)††† | 3051 (340) | 3124 (61) | 32.0*** | 0.7 | 3.5* |
| Hippocampus right | 3960 (53) | 3830 (66)# | 3760 (57) | 3389 (57)††† | 3905 (337) | 3172 (70)# | 19.7*** | 12.3*** | 5.4** |
| Amygdala left | 1501 (36) | 1439 (40)# | 1405 (37) | 1294 (37)††† | 1604 (171) | 1188 (42)# | 9.2*** | 11.0** | 2.5 |
| Amygdala right | 1567 (52) | 1535 (55) | 1522 (53) | 1398 (53)††† | 1612 (183) | 1290 (57) | 4.6** | 6.7** | 3.2* |
| Thalamus left | 6834 (101) | 6614 (119)# | 6951 (107) | 6689 (108)† | 6187 (564) | 6787 (126) | 1.1 | 0.04 | 1.1 |
| Thalamus right | 6388 (104) | 6320 (113) | 6419 (106) | 6173 (107)††† | 5600 (420) | 6185 (117) | 2.4 | 0.4 | 3.2* |
| Caudate left | 3419 (67) | 3336 (80) | 3571 (71) | 3407 (71)† | 4151 (393) | 3387 (85) | 2.9 | 6.1* | 1.7 |
| Caudate right | 3491 (88) | 3396 (98) | 3584 (91) | 3463 (91) | 4575 (407) | 3413 (103)# | 3.7* | 10.7** | 3.4* |
| Putamen left | 4831 (105) | 4779 (117) | 4689 (108) | 4609 (109) | 4692 (478) | 4509 (122) | 2.1 | 0.4 | 0.1 |
| Putamen right | 4627 (121) | 4607 (130) | 4659 (123) | 4461 (124)† | 4524 (444) | 4302 (134) | 0.6 | 0.9 | 1.5 |
| Pallidum left | 1366 (32) | 1412 (37) | 1370 (33) | 1385 (33) | 1488 (168) | 1390 (39) | 0.3 | 0.05 | 0.6 |
| Pallidum right | 1388 (26) | 1382 (31) | 1384 (28) | 1379 (28) | 1361 (148) | 1392 (33) | 0.02 | 0.01 | 0.03 |
| Accumbens left | 465 (23) | 432 (24)# | 434 (23) | 411 (23) | 526 (79) | 375 (25) | 2.1 | 6.7** | 1.5 |
| Accumbens right | 497 (22) | 467 (23)# | 466 (22) | 443 (22) | 425 (78) | 419 (24) | 2.3 | 4.0* | 0.6 |
| Average CT | 2.29 (0.02) | 2.28 (0.02) | 2.27 (0.02) | 2.22 (0.02)††† | 2.22 (0.07) | 2.19 (0.02) | 5.3** | 1.6 | 1.5 |
| CT Dickerson | 2.54 (0.02) | 2.52 (0.02) | 2.50 (0.02) | 2.45 (0.02)†† | 2.48 (0.09) | 2.38 (0.02) | 8.3*** | 3.5 | 1.6 |
| CT Jack | 2.68 (0.03) | 2.63 (0.03)# | 2.63 (0.03) | 2.56 (0.03)††† | 2.67 (0.10) | 2.47 (0.03)# | 6.7** | 9.3** | 1.7 |
Data presented as estimate (standard error). Estimates derived from linear mixed models including diagnosis × amyloid, age, gender and APOE ε4 genotype as covariates and cohort as random effect
APOE apolipoprotein E, CT cortical thickness, FDR false discovery rate, MRI magnetic resonance imaging
†pFDR < 0.05, ††pFDR < 0.01, †††pFDR < 0.001, #puncorrected < 0.05, compared to amyloid negative within diagnostic group
*p < 0.05, **p < 0.01, ***p < 0.001 for F statistic of main effect