Table 4.

Sensitivity, specificity, accuracy, PPV and NPV of the SVM classifier

Group	Sensitivity	Specificity	Accuracy	PPV	NPV	Threshold SVM
Optimized sensitivity and specificity
Cognitively normal	0.61	0.71	0.68	0.41	0.84	0.70
Mild cognitive impairment	0.71	0.77	0.74	0.84	0.62	0.33
Whole sample	0.75	0.79	0.77	0.80	0.74	0.48
80% sensitivity
Cognitively normal	0.80	0.55	0.62	0.41	0.88	0.77
Mild cognitive impairment	0.80	0.64	0.74	0.79	0.66	0.47
Whole sample	0.80	0.69	0.75	0.74	0.76	0.56
85% sensitivity
Cognitively normal	0.85	0.46	0.57	0.38	0.89	0.80
Mild cognitive impairment	0.85	0.54	0.73	0.75	0.68	0.53
Whole sample	0.85	0.59	0.73	0.69	0.78	0.64
90% sensitivity
Cognitively normal	0.90	0.36	0.51	0.35	0.91	0.84
Mild cognitive impairment	0.90	0.46	0.73	0.73	0.74	0.60
Whole sample	0.90	0.51	0.71	0.67	0.83	0.70
95% sensitivity
Cognitively normal	0.95	0.24	0.44	0.32	0.92	0.87
Mild cognitive impairment	0.95	0.37	0.73	0.71	0.83	0.70
Whole sample	0.95	0.40	0.69	0.63	0.88	0.79
100% sensitivity
Cognitively normal	1.00	0.11	0.36	0.30	1.00	0.91
Mild cognitive impairment	1.00	0.08	0.66	0.64	1.00	0.87
Whole sample	1.00	0.04	0.54	0.53	1.00	0.95

Results from combined classifier, including demographic information, neuropsychological tests, MRI measures and APOE ε4 genotype. Specific features selected presented in Additional file 1: Table S8. Values averaged across 10-fold cross-validation. Youden’s J statistic employed

APOE apolipoprotein E, MRI magnetic resonance imaging, NPV negative predictive value, PPV positive predictive value, SVM support vector machine