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. 2018 Jan 9;10(4):331–340. doi: 10.1093/jmcb/mjx051

Figure 2.

Figure 2

AKT promotes glycolysis in response to Nutlin. (A) Cells were treated with vehicle or Nutlin (10 μM) and/or MK2206 (10 μM) for 24 h. Lysates were immunoblotted for the indicated proteins. (B) The cells were also analyzed for glycolysis and relative glycolysis was presented with SD indicated. There is significant difference between Nutlin-treated and vehicle-treated MHM cells (P < 0.05) and A549 cells (P < 0.01) but no significant difference (P > 0.05) in U2OS cells. There is significant difference between Nutlin-treated and Nutlin plus MK2206-treated MHM (P < 0.05), A549 (P < 0.05), and U2OS (P < 0.05) cells.