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. 2017 Aug 18;2:9. doi: 10.1038/s41539-017-0011-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — GPCR RNAi screen. a Proportion of the population reversing to each stimulus for animals fed RNAi clones that increased the probability of a reversal to the final stimulus. Mean ±SEM. ‘#’ and ‘&’ denote significantly different groups based on the likelihood of responding to the final stimulus. b Proportion of animals reversing to the final stimulus for populations fed RNAi clones to knockdown egl-3 or one of 57 GPCRs. Knockdown was done in a background sensitized to neuronal RNAi by feeding: glr-1; lin-15b; sid-1; unc-119p::sid-1. Each circle is the mean of three plates, with multiple replicates for the control and egl-3 targeting vector. Dashed lines mark upper and lower critical values (values corresponding to |z-score| > 4.46; P < (0.05/57 =) 0.0008)