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. 2018 Feb 20;41(3):152–159. doi: 10.1177/0391398817752295

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Aggregate encapsulation. (a) Images of microwell and lid membrane used for preparation of sealed device. (b) and (c) Functionality of aggregates encapsulated within sealed flat device in comparison to free-floating aggregates after 1 day of culture, where (b) insulin concentration is obtained after glucose stimulation and (c) insulin secretion is normalized to the first low-glucose stimulation and presented as a stimulation index. Error bars indicate standard deviation (n = 3; **p < 0.05).