Table 3.
Current properties of CaV1.2 and CaV1.2-E4Q. Numerical values represent mean ± SEM. Statistical differences between mutants and controls were determined with unpaired Student’s t-test. Difference against control is represented as *(P-value).
| Ipeak (pA/pF) | Significance (P value) | V1/2 (mV) | Significance (P value) | Vrev (mV) | kact (mV) | Gmax (mV) | Tau (ms) | Ires200/Ipeak | n | |
|---|---|---|---|---|---|---|---|---|---|---|
| CaV1.2 | −12.6 ± 1.7 | 15.3 ± 1.6 | 86.7 ± 1.8 | 6.9 ± 0.4 | 233.1 ± 34.8 | 1.7 ± 0.2 | 0.55 ± 0.05 | 9 | ||
| CaV1.2-E4Q | −13.3 ± 1.7 | n.s. (0.7620) | 9.7 ± 1.6 | * (0.0254) | 87.5 ± 1.5 | 6.2 ± 0.5 | 305 ± 64.2 | 1.9 ± 0.2 | 0.52 ± 0.03 | 11 |