Table 2.

Averages and Medians of EC₅₀ and T_1/2 Values in Insulin-Responsive Kinases and their Substrates

Akt and Substrates
	pAkt (Ser473)	pAkt (Thr308)	pGsk3β	pFoxo1
EC50 (nM)	3.5	4.5	0.24	0.42
T1/2 (min)	2.7	2.7	2.7	8.0

mTOR Substrates and Effectors
	pS6K	peIF4ebp	pS6	peIF4b
EC50 (nM)	0.22	0.079	0.13	0.50
T1/2 (min)	7.3	16	20	11

MAPK and Substrates
	pErk1/2	pCreb	pp38	pAtf1	pJnk	pJun
EC50 (nM)	1.2	0.23	0.065	0.22	8.9	3.7
T1/2 (min)	2.5	2.7	2.5	5.5	20	27