Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Scheme illustrating the interaction between A1AT and TNFα in regulating neutrophil priming. A1AT hinders the ability of TNFα to interact with its receptor, thereby reducing the extent of neutrophil priming and subsequent degranulation. In GDM this system is skewed in favor of overt neutrophil priming due to enhanced TNFα levels concomitant with reduced A1AT concentrations.
