Table 1.
Preclinical studies: anxiolytic-like effects of cannabidiol after systemic administration in rodents.
| Animal model | Proposed related disorder | Species | CBD effects (dose range mg/kg) | References |
|---|---|---|---|---|
| SINGLE ADMINISTRATION | ||||
| Elevated plus maze, Vogel conflict test | Generalized anxiety | Rats | Anxiolytic (5–10 mg/kg, bell-shaped dose-response curve) | (19, 20) |
| Vogel conflict test | Generalized anxiety | Rats | Anxiolytic (10 mg/kg) | (21) |
| Fear conditioning expression | PTSD and generalized anxiety | Rats | Prevented fear expression (10 mg/kg) | (22) |
| Fear conditioning extinction | PTSD | Rats | Bidirectional effect (facilitated extinction when the conditioning stimulus was of high-intensity) | (23) |
| Reconsolidation of aversive memories | PTSD | Rats | Prevented reconsolidation (10 mg/kg) | (24, 25) |
| Marble burying | OCD | Mice | Anti-compulsive (15–60 mg/kg) | (26, 27) |
| REPEATED ADMINISTRATION | ||||
| CUS | Generalized anxiety and depression | Mice | Anti-stress (EPM and NSF; 30 mg/kg daily, 14 days) | (28) |
| Elevated T-maze | Panic disorder and generalized anxiety | Rats | Panicolytic (5 mg/kg/daily, 21 days) | (29) |
| Delayed responses to acute stress (predator exposure) | PTSD | Rats | Anxiolytic (5 mg/kg daily, 7 days) | (30) |
| Marble burying | OCD | Mice | Anti-compulsive (30 mg/kg daily, 7 days) | (26) |
EPM, elevated plus-maze; NSF, novel suppressed feeding; PTSD, post-traumatic stress disorder; OCD, obsessive-compulsive disorder; CUS, chronic unpredictable stress.