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. 2018 Aug 17;55(10):675–684. doi: 10.1136/jmedgenet-2017-105224

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Major angiogenesis pathways associated with genes identified in the present study. Major components and regulators of the BMP/TGF-β, VEGF, PI3K/Akt and Notch signalling pathways are presented in black. Genes in red harbour pathogenic variants; genes in orange harbour likely pathogenic variants; genes in yellow harbour variants of uncertain significance. Solid arrows indicate activation; solid bars indicate inhibition; dashed arrows indicate general interactions. TGF-β, transforming growth factor beta.