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. 2018 Jun 26;77(10):1516–1523. doi: 10.1136/annrheumdis-2017-212916

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Iberdomide (CC-220) inhibits (A) anti-dsDNA and (B) anti-phospholipid IgM (systemic lupus erythematosus) autoantibody production in vitro. In cultures of peripheral blood mononuclear cells from patients with systemic lupus erythematosus, CC-220 inhibited production of anti-dsDNA autoantibodies (n=9) and anti-phospholipid autoantibodies (n=8) with a half maximal inhibitory concentration of approximately 10 nM.