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. 2018 Jun 26;77(10):1516–1523. doi: 10.1136/annrheumdis-2017-212916

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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A single dose of iberdomide (CC-220) increased interleukin (IL)-2 production in (A) anti-CD3-stimulated whole blood and (B) decreases IL-1β production by lipopolysaccharide (LPS)-stimulated whole blood ex vivo in healthy volunteers. Subjects were randomised to single doses of placebo (0) or CC-220 0.03 mg (cohort A), 0.1 mg (cohort B), 0.3 mg (cohort C), 1 mg (cohort D) or 2 mg (cohort E). IL-2 (pg/mL) and IL-1β production by ex vivo anti-CD3 or LPS-stimulated whole blood, respectively, was measured as per cent of baseline at 3, 12 and 24 hours postdose. n=6 per CC-220 treatment group, n=10 for pooled placebo groups. *Data not available.