Fig. 3.
Effects of aerobic exercise on ACh-induced endothelium-dependent vasorelaxation in MAs. A Example of real-time recording of vascular contractility in mesenteric arterial rings in control (a), with Mel pretreatment (b), and with Luz + Mel pretreatment (c). B, C, and D Cumulative concentration–relaxation (%) curves for ACh (10−9–10−5 M) in MAs against NE in control, with Mel pretreatment, and with Luz + Mel pretreatment in WKY (B), SHR-SED (C), and SHR-EX (D). *P < 0.05, vs. control; #P < 0.05, vs. Mel. E, comparison of dose–response relations of ACh-induced vasorelaxation in WKY, SHR-SED, and SHR-EX in control (without Mel and Luz pretreatment). *P < 0.05, vs. WKY; #P < 0.05, vs. SHR-SED. Luz, luzindole (2 × 10−6 M); Mel, melatonin (10−4 M); NE, norepinephrine (10−5 M). Values were expressed as mean ± SEM, n = 6 in each group