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. 2018 Sep 24;10:3857–3865. doi: 10.2147/CMAR.S175681

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© 2018 He et al. This work is published and licensed by Dove Medical Press Limited

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CD44 is dysregulated in cancers and upregulated in hepatobiliary tumors.

Notes: (A) CD44 mRNA expression level in TCGA data analysis. CD44 mRNA was upregulated in tumor tissues of LIHC and CHOL. (B) Panoramic scanning for GBC TMA. (C) Representative CD44 staining in GBC tissues and normal samples. (D) Histological scoring of CD44 in GBC tissues and normal samples; CD44 was overexpressed in GBC tissues compared with the non-tumor tissues (P=0.0036). (E) Related CD44 mRNA expression in GBC tissues compared with paired non-tumor tissues (P<0.0001). ^*P<0.05.

Abbreviations: CD44, cluster of differentiation 44; TCGA, The Cancer Genome Atlas; LIHC, liver hepatocellular carcinoma; CHOL, cholangiocarcinoma; GBC, gallbladder cancer; TMA, tissue microarray; BLCA, bladder urothelial carcinoma; BRCA, breast cancer; COAD, colon cancer; ESCA, esophagus cancer; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, renal cancer; KIRP, kidney renal papillary cell carcinoma; LUAD, lung cancer; LUSC, lung squamous cell carcinoma; PRAD, prostate adenocarcinoma; READ, rectal cancer; STAD, stomach cancer; THCA, thyroid cancer; UCEC, uterine corpus endometrial carcinoma; ACC, adrenocortical carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; DLBC, lymphoid neoplasm diffuse large B-cell lymphoma; LAML, acute myeloid leukemia; LGG, brain lower drade glioma; MESO, mesothelioma; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; SARC, sarcoma; SKCM, skin cutaneous melanoma; TGCT, testicular germ cell tumors; THYM, thymoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma.