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. 2018 Sep 24;10:3857–3865. doi: 10.2147/CMAR.S175681

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© 2018 He et al. This work is published and licensed by Dove Medical Press Limited

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RNAi-mediated CD44 silencing inhibits in vitro GBC cells’ proliferation, migration and invasion.

Notes: (A) Dose-dependent CD44-siRNA downregulated the expression of CD44. (B) CCK-8 assay showed that CD44 silencing attenuated proliferation of GBC-SD and NOZ cells. (C) EDU assay confirmed that CD44 knockdown suppresses proliferation of GBC-SD and NOZ cells. (D) CD44 silencing caused a remarkable suppression of cell migration in GBC-SD and NOZ cells using wound-healing assay. (E) The invasiveness of GBC-SD and NOZ cells infected with CD44-siRNA was significantly suppressed according to cell invasion assay. ^**P<0.01.

Abbreviations: RNAi, RNA interference; CD44, cluster of differentiation 44; GBC, gallbladder cancer; NC, nonspecific control siRNA.