Table S1.

Baseline comorbidities/medical history of the two cohorts

Comorbidity	Non-MTDM (n=2,750)	MTDM (n=2,750)	|d|*
Acute myocardial infarction	125 (5%)	127 (5%)	0.00
Unstable angina	61 (2%)	68 (2%)	0.02
Stable angina	112 (4%)	127 (5%)	0.03
Coronary heart disease	586 (21%)	642 (23%)	0.05
Ischemic stroke	48 (2%)	51 (2%)	0.01
Peripheral artery disease	202 (7%)	222 (8%)	0.03
Type 1 diabetes	269 (10%)	257 (9%)	0.01
Type 2 diabetes	2683 (98%)	2706 (98%)	0.06
Hypertension	2226 (81%)	2226 (81%)	0.00
Hyperlipidemia	2391 (87$)	2391 (87%)	0.00
AIDS	3 (<1%)	2 (<1%)	0.01
Congestive heart failure	255 (9%)	282 (10%)	0.03
Chronic obstructive pulmonary disease	920 (33%)	920 (33%)	0.00
Dementia	15 (<1%)	7 (<1%)	0.05
Hemiplegia or paraplegia	12 (<1%)	8 (<1%)	0.02
Leukemia	6 (<1%)	7 (<1%)	0.01
Lymphoma	5 (<1%)	6 (<1%)	0.01
Any malignancy	218 (8%)	242 (9%)	0.03
Mild liver disease	137 (5%)	186 (7%)	0.08
Moderate to severe liver disease	8 (<1%)	9 (<1%)	0.01
Peptic ulcer disease	57 (2%)	58 (2%)	0.00
Rheumatic disease	101 (4%)	83 (3%)	0.04
Renal disease	488 (18%)	523 (19%)	0.03
Valvular disease	249 (9%)	308 (11%)	0.07
Bipolar disorder	36 (1%)	56 (2%)	0.06
Depressive disorder	695 (25%)	775 (28%)	0.07
Schizophrenia	21 (<1%)	15 (<1%)	0.03

Note:

^*|d| denotes standardized difference in means or percentages.

Abbreviation: MTDM, medication therapy disease management.