Table 2.
Subject characteristics according to SMC status
| CN n=175
|
MCI n=52
|
Early AD n=66
|
P-value
|
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|---|---|---|---|---|---|---|---|
| SMC (+) n=72 | SMC (−) n=103 | SMC (+) n=28 | SMC (−) n=24 | SMC (+) n=41 | SMC (−) n=25 | SMC (+) vs SMC (−) | |
|
|
|
|
|
|
|
|
|
| Age, years | 70.60±5.72 | 70.38±5.95 | 70.93±6.03 | 74.38±6.85 | 73.02±7.09 | 76.68±7.30 | 0.049c |
| Gender, male/female | 29/43 | 46/57 | 12/16 | 8/16 | 14/27 | 10/15 | |
| Education, years | 10.15±4.70 | 11.62±4.63 | 11.21±4.53 | 10.42±3.57 | 10.98±4.17 | 11.92±4.04 | 0.042a |
| Education | |||||||
| ≥7 | 51 (70.8) | 83 (80.6) | 20 (71.4) | 16 (66.7) | 30 (73.2) | 22 (88.0) | |
| <7 | 21 (29.2) | 20 (19.4) | 8 (28.6) | 8 (33.3) | 11 (26.8) | 3 (12.0) | |
| WLR | 5.82±1.38 | 6.07±1.57 | 1.93±0.94 | 1.71±0.86 | 1.93±1.52 | 1.44±1.50 | |
| MMSE | 26.46±1.91 | 26.83±1.72 | 25.71±1.49 | 25.42±1.64 | 22.20±1.49 | 21.72±1.62 | |
| CDR 0/0.5/1 | 72/0/0 | 103/0/0 | 0/28/0 | 0/24/0 | 0/31/10 | 0/19/6 | |
| CDR SOB | 0.00±0.00 | 0.00±0.00 | 1.43±0.60 | 1.29±0.66 | 3.40±1.27 | 3.70±1.61 | |
| BDS-ADL | 0.00±0.00 | 0.00±0.00 | 1.18±0.49 | 1.25±0.55 | 2.90±1.26 | 2.84±1.26 | |
| GDS | 14.01±7.04 | 9.63±6.28 | 13.68±6.57 | 8.50±5.45 | 12.68±6.05 | 9.00±6.88 | <0.001a 0.004b 0.026c |
| GDS | <0.001a | ||||||
| >15 | 30 (41.7) | 17 (16.5) | 9 (32.1) | 3 (12.5) | 12 (29.3) | 5 (20.2) | |
| ≤15 | 42 (58.3) | 86 (83.5) | 19 (67.9) | 21 (87.5) | 29 (70.7) | 20 (80.0) | |
| FAB | 14.53±1.94 | 14.61±2.20 | 13.96±2.52 | 13.63±1.95 | 12.50±3.42 | 11.12±3.86 | |
| mHIS | 1.24±1.88 | 0.89±1.35 | 1.11±1.34 | 1.54±2.50 | 0.59±0.74 | 0.52±0.65 | |
| ApoE ε4 carrier | 8 (15.7) | 15 (20.3) | 9 (32.1) | 10 (41.7) | 17 (44.7) | 3 (17.6) | |
Notes: Data are presented as mean±SD or number (%). Cutoff score of GDS is 15/16 for both minor depressive disorder and major depressive disorder. Group comparison was done by students’s t-test:
in the CN group, SMC (+) vs SMC (−);
in the MCI group, SMC (+) vs SMC (−);
in the AD group, SMC (+) vs SMC (−). Chi-square test was used to compare gender, categorized education, CDR, categorized GDS and ApoE ε 4 carrier status.
Abbreviations: CN, cognitively normal; MCI, mild cognitive impairment; AD, Alzheimer’s disease; WLR, word list delayed recall; MMSE, Mini-Mental State Examination; CDR, clinical dementia rating; SOB, sum of box; BDS-ADL, blessed Dementia Scale-Activities of Daily Living; GDS, Geriatric Depression Scale; FAB, Frontal Assessment Battery; mHIS, modified Hachinski Ischemic Scale; ApoE, apolipoprotein E; SMC, subjective memory complaint.