Table 2.
Univariate and multivariate analyses of OS in HER2+ breast cancer
| Parameters | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (years) | ||||
| ≥50 vs<50 | 1.083 (0.731–1.652) | 0.698 | 1.025 (0.632–1.686) | 0.896 |
| Tumor size | ||||
| ≥2 vs<2 | 3.542 (2.038–5.695) | <0.001 | 2.623 (1.562–4.652) | <0.001 |
| Lymph node metastasis | ||||
| Yes vs no | 2.532 (1.815–3.726) | <0.001 | 1.426 (0.897–2.356) | 0.132 |
| Histological grade | ||||
| G3 vs G1/2 | 2.651 (1.786–3.689) | <0.001 | 2.013 (1.262–3.562) | 0.001 |
| Lymphovascular invasion | ||||
| Yes vs no | 2.753 (1.952–3.856) | <0.001 | 1.653 (0.965–2.124) | 0.086 |
| BI-RADS | ||||
| 5 vs 3–4 | 2.285 (1.512–3.263) | <0.001 | 1.609 (1.216–2.351) | 0.015 |
| dNLR | ||||
| ≥2.5 vs<2.5 | 1.895 (1.152–2.862) | <0.001 | 1.726 (1.072–2.662) | 0.009 |
Abbreviations: BI-RADS, Breast Imaging-Reporting and Data System; dNLR, derived neutrophil-to-lymphocyte ratio; OS, overall survival.