Table 3.
Univariate and multivariate analyses of DFS in HER2+ breast cancer
| Parameters | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (years) | ||||
| ≥50 vs<50 | 0.963 (0.925–1.015) | 0.562 | 0.826 (0.652–1.162) | 0.216 |
| Tumor size | ||||
| ≥2 vs<2 | 2.862 (1.896–4.562) | <0.001 | 2.153 (1.352–3.653) | 0.002 |
| Lymph node metastasis | ||||
| Yes vs no | 2.256 (1.547–3.256) | <0.001 | 1.315 (0.863–2.153) | 0.268 |
| Histological grade | ||||
| G3 vs G1/2 | 3.256 (2.356–5.125) | <0.001 | 2.562 (1.796–4.152) | <0.001 |
| Lymphovascular invasion | ||||
| Yes vs no | 2.956 (2.036–4.352) | <0.001 | 2.263 (1.265–2.965) | 0.001 |
| BI-RADS | ||||
| 5 vs 3–4 | 2.562 (1.756–3.562) | <0.001 | 1.925 (1.526–2.635) | 0.021 |
| dNLR | ||||
| ≥2.5 vs<2.5 | 1.856 (1.325–2.976) | <0.001 | 1.658 (1.125–2.426) | 0.026 |
Abbreviations: BI-RADS, Breast Imaging-Reporting and Data System; DFS, disease-free survival; dNLR, derived neutrophil-to-lymphocyte ratio.