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Flnb A-to-I editing in ADAR2 knockout tissues. To confirm that ADAR2 enzyme is responsible for Flnb RNA editing different tissues were isolated from wild type and ADAR2 knockout mice and editing checked by Sanger sequencing. Adenosine to guanosine transitions were detected in ADAR2 wild type tissues only.
| ADAR2 | wild type | knockout |
|---|---|---|
| Cortex | 30,9% | 0% |
| Cerebellum | 42,7% | 0% |
| Heart | 62,3% | 0% |
| Skeletal muscle | 68,5% | 0% |
| Femur | 50,9% | 0% |
| Adipose tissue | 62,1% | 0% |
