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. 2018 Sep 7;9(70):33348–33359. doi: 10.18632/oncotarget.26072

Figure 6. Androgen Receptor is expression is highest in the HER2-positive and Luminal A/B subtypes.

Figure 6

(A-C) Scatter plots showing AR expression (log2) and the expression of markers for each molecular subtype. HER2 was used as a marker of the HER2+ subtype (A), PR for the Luminal A/B subtype (B) and Sox10 for the TNBC subtype (C). Each point represents an individual patient sample and is colour coded according to which subtype that sample stratified with from Figure 1. The dotted lines along the axes is used to visually quadrant the data points. For the subtype markers, this line corresponds to the mean expression value of the indicated gene across all 1246 patient samples, and for AR, the line was manually set at a value that splits the bimodal distribution of AR expression observed across cell types. (D-F) Identical plots to (A-C), but reduced to only samples from the HER2-positive (D), Luminal A/B (E) or TNBC (F) subtypes. The percentage of patient samples that fall within each quadrant of expression is provided. (G-I) The percentage of AR-low or AR-high expressing tumor samples within the HER2-positive (G), Luminal A/B (H) or TNBC (I) subtypes which express high levels of their corresponding markers (HER2, PGR and SOX10, respectively).