Figure 5. PEGylated Liposomal Encapsulation of the D- Arg Peptide inhibited growth of DU145 xenografts in mice.

2 million DU145 cells were injected subcutaneously in the abdominal flanks of nude mice. Once the tumor was palpable, mice were randomized into 3 groups (n = 4). Mice were injected then with D- Arg peptide (60mg/Kg) or with Liposomal D- peptide (100mg/Kg) every other day for 10 days. Control mice received saline. The Liposomal D-Arg peptide caused marked inhibited growth of the DU145 in mice compared to D-Arg peptide or control A., without causing weight loss or signs of toxicity B. Tumor size was measured every other day; tumor volume was measured using the formula (length x width²)/2. Data was plotted and SEM was calculated. **p-value equal to 0.05.