Table 3. Breast cancer biomarkers In Silico analysis: Metastasis vs primary*.
| Gene name | Metastasis vs primary | Fold change | P-value | Gene rank | Reference |
|---|---|---|---|---|---|
| CCNE2 | Metastasis vs primary | 1.681 | 0.058 | 2249 | Bittner Breast database 2005 |
| Metastasis vs primary | 1.214 | 0.307 | 3190 | Weigelt et al., 2003 | |
| Metastasis vs primary | –1.423 | 0.786 | 12226 | Radvanyi et al., 2005 | |
| Metastasis vs primary | –1.119 | 0.578 | 13819 | TCGA 2005 database | |
| CENPA | Metastasis vs primary | 2.464 | 0.032 | 168 | Weigelt et al., 2003 |
| Metastasis vs primary | 1.057 | 0.131 | 2895 | Haverty Breast | |
| Metastasis vs primary | 1.521 | 0.096 | 3298 | Bittner Breast database 2005 | |
| Metastasis vs primary | 1.828 | 0.155 | 4115 | Radvanyi et al.., 2005 | |
| LIN9 | Metastasis vs primary | 1.445 | 0.174 | 5203 | Bittner Breast database 2005 |
| Metastasis vs primary | –1.085 | 0.581 | 9471 | Radvanyi et al., 2005 | |
| Metastasis vs primary | –1.176 | 0.825 | 17493 | TCGA 2005 database | |
| RUNDC1 | Metastasis vs primary | 1.442 | 0.151 | 5579 | TCGA 2005 database |
| Metastasis vs primary | –1.059 | 0.52 | 8666 | Radvanyi et al.., 2005 | |
| Metastasis vs primary | –1.061 | 0.592 | 13627 | Bittner Breast database 2005 | |
| BRCA2 | Metastasis vs primary | –1.036 | 0.55 | 3551 | Sorlie et al, 2003 |
| Metastasis vs primary | –1.034 | 0.61 | 6852 | Weigelt et al., 2003 | |
| Metastasis vs primary | 1.09 | 0.326 | 8552 | Bittner Breast database 2005 | |
| Metastasis vs primary | –1.531 | 0.851 | 13239 | Radvanyi et al., 2005 | |
| Metastasis vs primary | –1.287 | 0.699 | 15588 | TCGA 2005 database | |
| CCNB1 | Metastasis (9) versus primary (327) | 1.506 | 0.05 | 2037 top 11% | Bittney database 2005 |
| Metastasis (5) versus primary (103) | –1.212 | 0.748 | 4538 top 74% | Sorlie et al., 2001 | |
| Metastasis (6) versus primary (4) | –1.313 | 0.807 | 8893 top 87% | Weigelt et al., 2003 | |
| Metastasis (7) versus primary (47) | –1.397 | 0.703 | 11075 top 67% | Radvanyi et al.., 2005 | |
| Metastasis (3) versus primary (529) | –1.133 | 0.687 | 15399 top 76% | TCGA 2005 database | |
| CDC25A | Metastasis vs primary | 1.673 | 0.014 | 828 | Bittner Breast database 2005 |
| Metastasis vs primary | –1.016 | 0.518 | 3417 | Sorlie et al, 2003 | |
| Metastasis vs primary | 1.098 | 0.357 | 3809 | Weigelt et al., 2003 | |
| Metastasis vs primary | 1.488 | 0.149 | 4018 | Radvanyi et al.., 2005 | |
| Metastasis vs primary | –1.407 | 0.76 | 16431 | TCGA 2005 database | |
| CDC25C | Metastasis vs primary | 2.248 | 0.017 | 932 | Bittner Breast database 2005 |
| Metastasis vs primary | 1.101 | 0.1 | 1140 | TCGA Breast 2 database | |
| Metastasis vs primary | 1.618 | 0.082 | 593 | Weigelt et al., 2003 | |
| CDKN2D | Metastasis vs primary | 1.415 | 0.01 | 224 | Sorlie et al, 2003 |
| Metastasis vs primary | 1.464 | 0.535 | 3559 | Bittner Breast database 2005 | |
| Metastasis vs primary | –1.02 | 6008 | Weigelt et al., 2003 |
*Novel phase-related genes in red on A column.