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. 2018 Aug 20;36(28):2845–2853. doi: 10.1200/JCO.2018.78.5246

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Fig 3. — Validation of the prognostic value of circulating tumor DNA (ctDNA). (A) Kaplan-Meier estimates of event-free survival (EFS) from the start of therapy for patients in cohort 2 stratified by pretreatment ctDNA levels are shown. The cut point separating high from low ctDNA was determined in cohort 1. (B) Kaplan-Meier estimates of EFS from the time of early molecular response (EMR) assessment for patients in validation set 2 achieving or not achieving EMR. (C) Kaplan-Meier estimates of EFS from the time of major molecular response (MMR) assessment for patients in validation set 2 achieving or not achieving MMR.