Table 3.
Relationships between mood and cluster analysis-identified chronobiological characteristics
| Variables | YMRS | IDS-30-C | ||||
|---|---|---|---|---|---|---|
| Unadjusted correlations r (p value) |
Adjusted linear regression RC (p value) | BHC p value |
Unadjusted correlations r (p value) |
Adjusted linear regression RC (p value) | BHC p value |
|
| IS | − 0.331 (0.0007)* | − 0.004 (0.005)* | 0.030* | 0.0005 (0.995) | 0.001 (0.25) | 0.956 |
| RA | − 0.391 (< 0.0001)* | − 0.005 (0.0003)* | 0.0021* | − 0.064 (0.523) | 0.001 (0.268) | 0.956 |
| GOF | − 0.333 (0.0006)* | − 0.003 (0.017)* | 0.051a | − 0.099 (0.32) | − 0.00 (0.956) | 0.956 |
| CQ | − 0.217 (0.027)* | − 0.005 (0.006)* | 0.030* | 0.057 (0.565) | 0.002 (0.181) | 0.956 |
| 24-h correlation | − 0.317 (0.001)* | − 0.003 (0.623) | 0.623 | − 0.152 (0.124) | − 0.00 (0.623) | 0.956 |
| SRM-5 | − 0.218 (0.0325)* | − 0.026 (0.09)a | 0.180 | − 0.038 (0.696) | 0.004 (0.741) | 0.956 |
| PSQI | 0.351 (0.0003)* | 0.111 (0.012)* | 0.048* | 0.396 (< 0.0001)* | 0.099 (0.005)* | 0.035* |
The relationships between mood rating scale scores and variables characterizing biorhythms. Unadjusted correlations as well as linear regression results adjusted for age, gender, and medication class use (lithium, anticonvulsants, antidepressants, antipsychotics, benzodiazepines) are shown. r denotes correlation coefficient and RC denotes regression coefficient
IS interdaily stability, IV intradaily variability, RA relative amplitude, CQ circadian quotient, GOF goodness-of-fit, SRM-5 5-Item Social Rhythm Metric, PSQI Pittsburgh Sleep Quality Index, YMRS Young Mania Rating Scale, IDS-30-C 30-Item Inventory of Depressive Symptomatology. BHC Benjamini–Hochberg Correction for multiple testing
* and italic font denotes statistical significance
aDenotes a trend toward significance