Table 4.
Associations between cofactors and chronobiological variables
| IS RC (p value) |
RA RC (p value) |
GOF RC (p value) |
CQ RC (p value) |
24-h correlation RC (p value) |
SRM-5 RC (p value) |
PSQI RC (p value) |
|
|---|---|---|---|---|---|---|---|
| Medications | |||||||
| Li | 0.07 (0.054)a | 0.06 (0.082)a | 0.07 (0.037)* | 0.04 (0.377) | 0.07 (0.023)* | 0.11 (0.725) | 1.57 (0.127) |
| AC | − 0.03 (0.20) | − 0.03 (0.255) | − 0.02 (0.335) | 0.008 (0.806) | − 0.03 (0.228) | − 0.06 (0.813) | − 0.18 (0.821) |
| AD | − 0.05 (0.078)a | − 0.07 (0.004)* | − 0.05 (0.031)* | − 0.04 (0.178) | − 0.05 (0.03)* | − 0.39 (0.128) | 1.46 (0.07)a |
| AP | 0.00 (0.974) | 0.02 (0.322) | − 0.02 (0.355) | − 0.03 (0.322) | − 0.03 (0.168) | 0.05 (0.859) | − 0.37 (0.646) |
| BZD | − 0.03 (0.378) | − 0.03 (0.295) | − 0.01 (0.691) | − 0.01 (0.766) | − 0.01 (0.751) | − 0.42 (0.15) | 1.24 (0.176) |
| Other covariates | |||||||
| Age | 0.0004 (0.75) | − 0.001 (0.198) | − 0.0003 (0.769) | − 0.0002 (0.86) | − 0.001 (0.272) | 0.014 (0.19) | 0.042 (0.235) |
| Gender (female) | 0.074 (0.015)* | 0.052 (0.062)a | 0.072 (0.004)* | 0.09 (0.007)* | 0.054 (0.034)* | 0.172 (0.517) | 0.23 (0.779) |
The table highlights the associations between cofactors and chronobiological variables identified via cluster analysis. Results are presented as regression coefficients (RC) and associated p values
Li lithium, AC anticonvulsants, AD antidepressants, AP antipsychotics, BZD benzodiazepines. IS interdaily stability, IV intradaily variability, RA relative amplitude, CQ circadian quotient, GOF goodness-of-fit, SRM-5 5-Item Social Rhythm Metric, PSQI Pittsburgh Sleep Quality Index
* and italic font denotes statistical significance
aDenotes a trend toward significance