Table 3.

Comparison of liver perfusion rates to measured rates of hepatic clearance by isolated perfused livers

Chemical	Qipl (mL/h/g liver)	BSA protein (g/L)	CLipl,meas (mL/h/g liver)	CLipl,meas/Qipl (as %)
Naphthalene	74.3	1	8.3 ± 0.1	11.2
		10	2.7 ± 0.2	3.6
Fluorene	85.8	1	41.8 ± 10.9	48.7
		10	26.2 ± 9.1	30.5
Anthracene	75.2	1	66.6 ± 13.3	88.5
		10	48 ± 7.6	63.8
Phenanthrene	79.7	1	61.9 ± 15.2	77.7
		10	43.4 ± 11.7	54.5
Pyrene	82.1	1	62.7 ± 2.9	76.4
		10	68.2 ± 3.3	83.0
Benzo[a]pyrene	70.1	1	58 ± 13	82.8
		10	50.6 ± 4.2	72.2

Qipl = average perfusion rate; BSA = bovine serum albumin; CLipl,meas = measured hepatic clearance by perfused livers; data reported as mean ± SD