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Structure of human a-CAs bound to a “non-classical” sulfonamide inhibitor. Surface depiction of a substituted coumarin bound to the active site of (A) CA II, PDB ID 5BNL (grey), (B) CA IX, PDB ID 3IAI (green), (C) CA XII, PDB ID IJCZ (wheat). Active site zinc (magenta sphere), hydrophilic (purple) and hydrophobic (orange) residues are shown.
