Table 1.
Catalytic Efficiency, Distribution and Associated Diseases of CA II, IX and XII [1].
| Isozyme | Kcat (s−1) |
KM (mM) |
Kcat /KM (M−1 s−1) |
Oligomeric State |
Tissue/Organ Localization |
Subcellular Localization/Associated disease |
|---|---|---|---|---|---|---|
| CA II | 1.4 × 106 | 9.3 | 1.5 × 108 | Monomer | RBC, kidney, brain, lung, testis, osteoclasts, eye, GI tract | Cytosol/ Glaucoma, epilepsy, edema, altitude sickness |
| CA IX | 3.8 × 105 | 6.9 | 5.5 × 107 | Dimer | GI mucosa, tumors | Transmembrane/ Cancer |
| CA XII | 4.2 × 105 | 12.0 | 3.5 × 107 | Dimer | Eye, tumors, reproductive epithelia, intestines, and kidney | Transmembrane/ Cancer, glaucoma |