Table 2.
Cox proportional hazard ratios of risk for Alzheimer’s disease
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | |
| Age | 1.06 (1.03, 1.09) | .000 | 1.04 (1.00, 1.07) | .025 | 1.04 (1.00, 1.07) | .022 |
| Education | 0.99 (0.92, 1.08) | .933 | ||||
| Sex | 0.89 (0.57, 1.39) | .623 | ||||
| MMSE | 0.79 (0.70, 0.90) | .000 | 0.85 (0.75, 0.97) | .017 | ||
| AVLT-DR | 0.89 (0.83, 0.95) | .000 | 0.92 (0.86, 0.97) | .005 | ||
| FDG-PET | 0.95 (0.94, 0.97) | .000 | ||||
| 1 APOE ε4 allele | 1.51 (0.92, 2.47) | .105 | ||||
| 2 APOE ε4 alleles | 1.92 (0.99, 3.71) | .052 | ||||
| PE tn-2 10% | -- | 1.73 (1.10, 2.72) | .017 | 1.58 (1.00, 2.48) | .047 | |
| PE tn-2 7% | -- | 1.94 (1.23, 3.06) | .004 | 1.79 (1.13, 2.81) | .012 | |
| PE tn-2 5% | -- | 2.10 (1.33, 3.33) | .002 | 1.93 (1.22, 3.05) | .005 | |
MMSE: Mini-Mental State Examination. AVLT-DR: baseline Auditory Verbal Learning Test delayed recall scores. FDG-PET: fluorodeoxyglucose positron emission tomography (N = 627). APOE: apolipoprotein E-4. PE tn-2: practice effects using a tn-2 distribution as defined in the text. HR: hazard ratio. CI: confidence interval. Separate backward stepwise Cox regressions were performed for PE tn-2 10%, PE tn-2 7% and PE tn-2 5%