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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: Mucosal Immunol. 2018 Jun 15;11(5):1375–1385. doi: 10.1038/s41385-018-0048-x

Figure 1. Local sinonasal complement protein expression is associated with increased subjective disease severity.

Figure 1

A. Quantification of systemic circulating plasma C3 concentrations in controls and patients with CRSwNP. B. Correlation analysis between circulating C3 and subjective disease severity as measured by the sinonasal outcome test-22 (SNOT22) C. Volcano plot of shotgun proteomics results. Normalized spectral counts were used to compare protein abundance between CRSwNP and control mucus samples. The majority of the 466 identified proteins were decreased in CRSwNP (77.3%). D. Top 10 Enriched REACTOME Pathways. Using just the differentially abundant proteins that were increased in CRSwNP, pathway enrichment was performed against the REACTOME database. The top 10 pathways based on combined score are shown. E. Pearson correlation analysis demonstrating a positive correlation between nasal mucus levels of C3 and subjective disease severity in patients with CRSwNP. NSc = normalized spectral counts.