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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: Mucosal Immunol. 2018 Jun 15;11(5):1375–1385. doi: 10.1038/s41385-018-0048-x

Figure 3. CRSwNP-derived HSNEC have a heightened release of C3 and C3a upon Aspergillus Fumigatus (Af) extract challenge.

Figure 3

Surface, intracellular and total C3 (A) and C3a (B) levels in unstimulated HSNEC show that CRSwNP HSNEC have increased intracellular stores of C3 as compared to those from control subjects. * p<0.05 between indicated groups. ELISA measurement of (C) C3, (D) C3a, (E) C4, (F) C5, and (G) fB in HSNEC culture supernatants following exposure to increasing doses of Af extract. Note that CRSwNP cells had significantly more C3, C3a, C4, C5 and fB as compared to control. Values shown are mean+SD. *p<0.05 vs dose-matched control. n=4/group.