Table 1.
Observed Sex Differences Following Lateral Habenula CB1R Manipulation or Chronic Unpredictable Stress Exposure.
| Endpoint Measured | ♂ | ♀ |
|---|---|---|
| CB1R Manipulation Studies | ||
| Basal CORT | ||
| RIM Effect | ↑ | –– |
| Acute Stress CORT (AUC) | ||
| WIN Effect | ↓ | –– |
| FST Swimming Time | ||
| WIN Effect | ↓ | –– |
| EPM Open Arm Distance | ||
| RIM Effect | ↑ | –– |
| WIN Effect | ↑ | –– |
| NSF Latency To Eat | ||
| RIM Effect | ↓ | –– |
| Chronic Unpredictable Stress Studies | ||
| Percent LHb Spikes in Burst | ||
| CUS Effect | ↑ | –– |
| LHb Burst Interspike Interval | ||
| CUS Effect | –– | ↑ |
| MAGL Vmax | ||
| CUS Effect | ↑ | ↑ |
| MAGL Km | ||
| CUS Effect | ↑ | ↑ |
| CB1R Bmax | ||
| CUS Effect | ↓ | ↓ |
| CB1R Kd | ||
| CUS Effect | ↓ | –– |
↓↑ = Significant Increase/Decrease, ↓↑ = Trend (p=0.051-0.10), –– = No Change