Table 1.
Endpoint Measured | ♂ | ♀ |
---|---|---|
CB1R Manipulation Studies | ||
Basal CORT | ||
RIM Effect | ↑ | –– |
Acute Stress CORT (AUC) | ||
WIN Effect | ↓ | –– |
FST Swimming Time | ||
WIN Effect | ↓ | –– |
EPM Open Arm Distance | ||
RIM Effect | ↑ | –– |
WIN Effect | ↑ | –– |
NSF Latency To Eat | ||
RIM Effect | ↓ | –– |
Chronic Unpredictable Stress Studies | ||
Percent LHb Spikes in Burst | ||
CUS Effect | ↑ | –– |
LHb Burst Interspike Interval | ||
CUS Effect | –– | ↑ |
MAGL Vmax | ||
CUS Effect | ↑ | ↑ |
MAGL Km | ||
CUS Effect | ↑ | ↑ |
CB1R Bmax | ||
CUS Effect | ↓ | ↓ |
CB1R Kd | ||
CUS Effect | ↓ | –– |
↓↑ = Significant Increase/Decrease, ↓↑ = Trend (p=0.051-0.10), –– = No Change