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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Exp Clin Psychopharmacol. 2018 Jun 28;26(5):488–496. doi: 10.1037/pha0000209

Figure 2.

Figure 2

Predicted (open circles; dashed line) and observed (circles; solid line) effects of mixtures of lorcaserin and buspirone on cocaine infusions (0.032 mg/kg) earned under a PR schedule of reinforcement (n=4; 2 males and 2 females). Mixtures of lorcaserin and buspirone were evaluated at three fixed dose ratios (3:1, 1:1, and 1:3) relative to the ID50 value for each drug from individual subjects. Abscissa: mean (± 1 SEM) of the total mixture dose, expressed in mg/kg of lorcaserin equivalents, administered SC 15 min before the start of the session. Ordinate: percent of baseline infusions expressed as the mean (± 1 SEM) for the number of infusions earned following pretreatment with mixtures of lorcaserin and buspirone relative to the average number of infusions earned during the two preceding baseline sessions.