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. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: Biol Psychiatry. 2018 May 3;84(8):601–610. doi: 10.1016/j.biopsych.2018.04.016

Figure 2. Reinstatement following THC+CBD or Vehicle self-administration.

Figure 2

A) Cue- (left) and yohimbine-induced (2.5 mg/kg, ip) reinstatement in rats trained to self-administer THC+CBD +p<0.05, comparing active and inactive lever pressing. *p<0.05, comparing active lever pressing between reinstatement and extinction. THC-prime (right, 1 mg/kg, ip) did not reinstate lever pressing. B) Lack of cue-, yohimbine, and THC-primed reinstatement compared to extinction lever pressing in vehicle self-administering rats. +p<0.05, comparing active and inactive lever pressing. C) THC+CBD prime (1 + 0.1 mg/kg, ip) and vehicle did not reinstate lever pressing in THC+CBD extinguished rats here performed using within subject crossover of vehicle prime. N is shown over or within the bars. (See Table S2 for complete statistics).