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Model for C-terminal tail/DNA-binding switch of gp2.5. The C-terminal tail of gp2.5 binds to the positively-charged DNA-binding cleft, oscillating between bound and bound states. This oscillation allows gp2.5 to sense for the presence of ssDNA and prevents interaction with random negatively charged surfaces. For simplicity, we depict a gp2.5 monomer binding its C-terminal tail through its own DNA-binding surface.
