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Interaction between the TBD of gp5 and the C-terminal tail of gp2.5. Top panel: Binding of thioredoxin to gp5 leads to the formation of two positively-charged loops, TBD loops A and B (residues 275–285 and residues 299–314 of gp5, blue dashed lines). Bottom panel: When gp2.5 binds ssDNA (gray), its free acidic C-terminal tail (red) interacts electrostatically with TBD loops A and B (blue).
