Table 3.
Abnormal laboratory results in asymptomatic patients at scheduled appointments
| Asymptomatic | |||
|---|---|---|---|
| FBE (all patients; n = 2191) | LDH (NHL; n = 1095) | ESR (HL; n = 343) | |
| No. abnormal results | 190/2191 (9%) | 99/1095 (9%) | 17/1343 (5%) |
| Degree of abnormality | |||
| <2 × ULN | N/A | 98 (99%) | 16 (94%) |
| >2 × ULN | 1 (1%) | 1 (6%) | |
| Change in management: | 29/190 (15%) | 16/99 (16%) | 3/17 (18%) |
| Earlier subsequent review | 6 | 2 | 0 |
| Additional lab tests | 16 | 10 | 2 |
| Imaging | 4 | 3 | 1 |
| Biopsy | 3 | 1 | 0 |
| Specific abnormality resulting in change in management | Leukopaenia 13 | <2 × ULN: 15 | <2 × ULN: 3 |
| Leukocytosis 4 | >2 × ULN: 1 | ||
| Anaemia 4 | |||
| Thrombocytopaenia 4 | |||
| Pancytopaenia 3 | |||
| Thrombocytosis 1 | |||
| Relapse detected due to further investigation of labs | 0 | 1 | 1 |
| Relapse within 3 months of abnormalitya | 5 | 4 | 1 |
aIncluding cases where relapse was diagnosed only after symptoms developed