Fig. 2.

Cisplatin and rucaparib responses in BRCA1/2 mutant and HR wild-type HGSOC PDX. Rucaparib and cisplatin response in a PDX #56 (BRCA1 mutant); b PDX #19 (BRCA2 mutant); c PDX #201 (HR-DNA repair gene wild-type); and d PDX #29 (HR-DNA repair gene wild-type). Recipient mice bearing PDX were randomized to treatment with vehicle or rucaparib, at the dose shown. PDX were harvested at a tumor volume of 600–700 mm³. Cisplatin response data for PDX #19, #56, and #29 were previously published³⁴. See Table 1 and Supplementary Data 2 for median TTH and p-values for survival comparison. Mean tumor volume (mm³) ± 95% CI (hashed lines are representing individual mice) and corresponding Kaplan–Meier survival analysis. Censored events are represented by crosses on Kaplan–Meier plot; n = individual mice