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. 2018 Sep 28;9:3983. doi: 10.1038/s41467-018-06499-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic illustration for the probes’ response in vivo and related properties. a Schematic illustration for two xanthene-based molecules (C¹X-OR¹ and C²X-OR²) as the activatable OA probes for respectively imaging liver injury and metastatic tumor. b and c Absorption spectra for the probes (5 μM) and their corresponding activated forms (C¹X-OH and C²X-OH, 3 μM). d Structure of a hepatocyte-targeting phospholipid for liver targeting. e and f Transmission electron microscopic image and particle diameter distribution for a liposomal C¹X-OR¹ sample. Scale bar: 200 nm