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. 2018 Sep 28;8:14540. doi: 10.1038/s41598-018-32752-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The simultaneous changes in prefrontal Oxy-Hb, forehead and cheek skin blood flow, and arterial blood pressure (AP) during conversation are represented in one subject. When conversation was made by asking the subjective ratings of pleasantness and consciousness, an increase in the prefrontal Oxy-Hb was observed on both sides, despite no change in the prefrontal Deoxy-Hb (not shown). Facial skin blood flow and AP did not represent substantial changes during conversation.