Figure 1.

Host immune response against Sporothrix spp. (1) Infection with Sporothrix occurs by the traumatic inoculation of yeasts, conidia, or hyphae. Once the fungus crosses the primary barriers of the immune system, (2) components of the pathogen trigger the innate immune response including cells and molecules to attack the invader. (3) Several molecules of the fungus active T cells by being presented as antigens (i.e., peptides of Gp70). (4) Protective antibodies against the fungus are generated. All of this is for the clearance of the pathogen. MNC: Mononuclear cells. PMNC: Polymorphonuclear cells. NK: Natural Killer cells. Black arrows: infection sequence. Red arrows: increased production and participation during infection. Orange arrow: increased secretion during infection.